Description

Benazepril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used primarily as an active pharmaceutical ingredient (API). Its primary value lies in its efficacy for managing hypertension and heart failure, offering a critical therapeutic option for cardiovascular health. This high-purity compound is essential for pharmaceutical manufacturers engaged in the formulation of prescription medications, particularly in the production of tablets and other solid dosage forms. Global suppliers require a reliable source that guarantees consistent quality and strict adherence to pharmacopeial standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and heart failure medications.
• Tablet Formulation: Key component in the manufacture of oral solid dosage forms, including immediate and controlled-release tablets.
• Cardiovascular Drug Production: Essential for compounding drugs targeting the renin-angiotensin-aldosterone system (RAAS).
• Research & Development: Used as a reference standard and in preclinical studies for cardiovascular pharmacology.
• Generic Drug Manufacturing: Critical for producing cost-effective generic versions of branded ACE inhibitor drugs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug production.

Basic Information

Product Name	Benazepril
CAS No.	131064-74-9
Molecular Formula	C24H28N2O5•HCl
Molecular Weight	460.95 g/mol (as hydrochloride)
Synonyms	Benazepril Hydrochloride; CGS-14824A; CGS 14824; (3S)-3-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride; Benzazepril; Lotensin (Brand Name API)
EINECS	Contact for details

Quality Control

Our Benazepril is manufactured under strict quality systems to meet or exceed major pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with each shipment to ensure full traceability and compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	-165° to -175° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.