Description

Sampatrilat CAS NO 129981-36-8 is a potent and selective vasopeptidase inhibitor, a dual-acting compound that targets both angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). This mechanism is significant for its role in cardiovascular research, particularly in the study of hypertension and heart failure pathways. It is an essential reference standard and key intermediate for pharmaceutical R&D teams, medicinal chemists, and contract research organizations (CROs) engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in API manufacturing.
• Cardiovascular Research: A critical tool for in vitro and in vivo studies investigating the pharmacology of vasopeptidase inhibition and its effects on blood pressure regulation.
• Medicinal Chemistry Intermediate: Serves as a key building block or precursor in the synthetic route for developing new chemical entities within the vasopeptidase inhibitor class.
• Biochemical Assay Development: Employed in enzymatic assays to screen for and characterize ACE and NEP inhibitory activity.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Utilized as an analytical standard to quantify drug levels and metabolite profiling in biological matrices during preclinical studies.

Basic Information

Product Name	Sampatrilat
CAS No.	129981-36-8
Molecular Formula	C20H28N2O5S
Molecular Weight	408.51 g/mol
Synonyms	UK-81252; (2R)-2-[(3S)-3-[(2S)-2-Acetylsulfanyl-3-methylbutanoyl]amino-2-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-5-yl]-4-methylpentanoic acid; UK 81252; UK81252; Sampatrilatum; UNII-6Q6U0E8Q8H
EINECS	Contact for details

Quality Control

Our Sampatrilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity, identity confirmation (IR, MS), and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.