Description

(2R)-Ramipril is the pharmacologically active enantiomer of the well-known ACE inhibitor, Ramipril. This high-purity chiral intermediate is critical for the synthesis of advanced cardiovascular pharmaceuticals, ensuring optimal therapeutic efficacy and minimizing potential side effects. It is an essential building block for pharmaceutical manufacturers and R&D institutions focused on developing and producing enantiomerically pure antihypertensive and cardioprotective drugs.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral intermediate in the commercial production of Ramipril and its pharmaceutical formulations.
• Cardiovascular Drug Development: Critical raw material in R&D for new and generic antihypertensive, heart failure, and post-myocardial infarction medications.
• Enantioselective Synthesis Studies: Used as a reference standard and starting material in academic and industrial research exploring stereoselective chemical processes.
• Pharmaceutical Impurity Profiling: Serves as a high-purity reference standard for quality control laboratories to identify and quantify related substances in Ramipril batches.
• Metabolite Research: Employed in pharmacokinetic and metabolic studies to understand the drug's pathway and activity in biological systems.

Basic Information

Product Name	(2R)-Ramipril
CAS No.	129939-65-7
Molecular Formula	C23H32N2O5
Molecular Weight	416.52 g/mol
Synonyms	(2R)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dihydro-1H-cyclopenta[b]pyridine-4-carboxylic acid; (2R,3aS,6aS)-1-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; Ramipril Enantiomer; (R)-Ramipril; (2R)-Ramiprilat Precursor
EINECS	Contact for details

Quality Control

Our (2R)-Ramipril is manufactured under strict quality management systems, with specifications designed to meet the rigorous demands of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and the absence of critical impurities. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to align with specific pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.