Description

(2R,3Ar,6Ar)-Ramipril is a high-purity stereoisomer of the active pharmaceutical ingredient Ramipril, a well-established angiotensin-converting enzyme (ACE) inhibitor. This specific enantiomer is critical for ensuring the intended pharmacological activity and therapeutic efficacy in final drug formulations. It is an essential intermediate and reference standard for pharmaceutical manufacturers and research institutions developing and producing cardiovascular medications, particularly for hypertension and heart failure treatment.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key chiral building block in the commercial synthesis of Ramipril and its pharmaceutical salts.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control, method validation, and regulatory compliance in analytical laboratories.
• Research & Development: Used in preclinical and clinical studies to investigate the pharmacokinetics, metabolism, and structure-activity relationships of ACE inhibitors.
• Generic Drug Manufacturing: A critical starting material for companies producing bioequivalent generic versions of Ramipril-based medications.
• Process Chemistry & Optimization: Employed in scaling up and optimizing synthetic routes for more efficient and cost-effective API production.

Basic Information

Product Name	(2R,3Ar,6Ar)-Ramipril
CAS No.	129939-63-5
Molecular Formula	C23H32N2O5
Molecular Weight	416.51 g/mol
Synonyms	(2R,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid; (2R,3aS,6aS)-Ramipril; Ramipril Stereoisomer; Ramipril EP Impurity C; (2R,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (2R,3Ar,6Ar)-Ramipril is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and related substance analysis, to ensure it meets stringent pharmacopeial standards such as USP and EP. A detailed Certificate of Analysis (COA) providing full chromatographic and spectroscopic data is supplied with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.