Description

(S)-(+)-Manidipine is the pharmacologically active enantiomer of the calcium channel blocker manidipine. This high-purity chiral intermediate is critical for the synthesis of advanced antihypertensive pharmaceuticals, offering superior selectivity and potency. It is essential for research institutions and pharmaceutical manufacturers focused on developing and producing enantiomerically pure cardiovascular drugs. The compound is supplied as (S)-(+)-Manidipine CAS NO 126451-47-6 to ensure precise identification and sourcing.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use in the synthesis of the S-enantiomer of manidipine dihydrochloride, a potent calcium channel blocker.
• Pharmaceutical R&D: Critical chiral building block for investigating structure-activity relationships and developing new enantiopure cardiovascular therapies.
• Process Chemistry & Scale-up: Used in optimizing synthetic routes for the commercial production of antihypertensive medications.
• Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Preclinical Studies: Employed in pharmacological and toxicological studies to evaluate the efficacy and safety profile of the specific enantiomer.

Basic Information

Product Name	(S)-(+)-Manidipine
CAS No.	126451-47-6
Molecular Formula	C35H38N4O6
Molecular Weight	610.70 g/mol
Synonyms	(+)-Manidipine; (S)-Manidipine; Manidipine S-enantiomer; (3S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester; CAS 126451-47-6; (S)-(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester
EINECS	Contact for details

Quality Control

Our (S)-(+)-Manidipine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and intermediate use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.