Description

Manidipine Hydrochloride CAS NO 126372-04-1 is a high-purity pharmaceutical active ingredient belonging to the dihydropyridine class of calcium channel blockers. It is a critical intermediate and reference standard in the research, development, and quality control of antihypertensive medications. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and R&D institutions focused on cardiovascular therapeutics.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in the formulation of antihypertensive and antianginal drugs.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing in pharmaceutical laboratories.
• Research & Development: Used in preclinical and clinical studies to investigate its mechanism of action, pharmacokinetics, and pharmacodynamics.
• Process Development: Employed as a benchmark in the development and optimization of synthetic routes for manidipine and related analogs.
• Impurity Profiling: Utilized to identify, quantify, and control related substances and degradation products in drug substance and drug product manufacturing.
• Educational & Analytical Use: Serves as a pure compound for academic research and training in medicinal chemistry and pharmacology.

Basic Information

Item	Details
Product Name	Manidipine Hydrochloride
CAS No.	126372-04-1
Molecular Formula	C35H38N4O6 · HCl
Molecular Weight	647.16 g/mol
Synonyms	Manidipine HCl; (±)-Manidipine Hydrochloride; 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride; Calslot; Manyper; CV-4093; CV 4093; CV4093
EINECS	Contact for details

Quality Control

Our Manidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.