Description

Manidipinehcl CAS NO 126229-12-7 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical component in the synthesis of antihypertensive medications, valued for its precise pharmacological activity and consistent quality. This compound is essential for pharmaceutical manufacturers, research institutions, and chemical suppliers engaged in cardiovascular drug development and production.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of antihypertensive and antianginal drugs.
• Cardiovascular Research: A key reference standard and investigational compound in pharmacological studies targeting calcium channels.
• Generic Drug Manufacturing: Serves as a core building block for producing generic versions of calcium channel blocker medications.
• Chemical Intermediate: Used in advanced organic synthesis for creating novel dihydropyridine derivatives with potential therapeutic benefits.
• Analytical Standard: Employed in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Preclinical Development: Utilized in formulation studies and stability testing during the drug development pipeline.

Basic Information

Product Name	Manidipinehcl
CAS No.	126229-12-7
Molecular Formula	C35H38N4O6 • HCl
Molecular Weight	647.16 g/mol (as hydrochloride salt)
Synonyms	Manidipine Hydrochloride; (±)-Manidipine Hydrochloride; Calslot; Manidipine HCl; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride; CV-4093-2HCl; FR-34235
EINECS	Contact for details

Quality Control

Our Manidipinehcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under inert conditions if the container is opened repeatedly to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.