Description

Lemildipine is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the class of dihydropyridine calcium channel blockers. This compound is critical for the research, development, and production of next-generation cardiovascular therapeutics targeting hypertension and angina. It is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in cardiovascular drug discovery and formulation. Our supply ensures the stringent quality and consistency required for advanced pharmaceutical applications.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of calcium channel blocker medications.
• Cardiovascular Drug Development: Key intermediate in the R&D of new antihypertensive and antianginal drugs.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Biochemical Research: Used in pharmacological studies to investigate calcium channel mechanisms and vascular smooth muscle function.
• Preclinical Studies: Employed in animal model research to evaluate the efficacy and pharmacokinetics of new cardiovascular formulations.
• Process Chemistry: Acts as a critical building block in the scale-up and optimization of synthetic routes for dihydropyridine derivatives.

Basic Information

Product Name	Lemildipine
CAS No.	125729-29-5
Molecular Formula	C20H24N2O6
Molecular Weight	388.42 g/mol
Synonyms	Lemildipine; FRC-8653; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; 3-[2-(Benzylmethylamino)ethyl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (±)-Lemildipine; FRC 8653; UNII-2V6Q5IWM8R
EINECS	Contact for details

Quality Control

Our Lemildipine CAS NO 125729-29-5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.