Description

(R)-(+)-Norverapamil Hydrochloride is a high-purity, single-enantiomer pharmaceutical intermediate and research chemical. This compound is a key chiral building block in the synthesis and pharmacological study of calcium channel blockers, offering critical value for stereoselective research and development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for cardiovascular drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of advanced verapamil analogs and other calcium channel antagonists.
• Pharmacological Research: Used as a reference standard and active agent in in vitro and in vivo studies to investigate stereospecific calcium channel modulation.
• Metabolite Studies: Serves as a key metabolite of verapamil for pharmacokinetic and drug metabolism research.
• Analytical Standard: Employed in HPLC, LC-MS, and chiral chromatography for method development, validation, and quality control.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) assays to identify and characterize new cardiovascular drug candidates.
• Academic Research: Supports fundamental studies in medicinal chemistry, cardiology, and neuropharmacology at universities and research institutes.

Basic Information

Product Name	(R)-(+)-Norverapamil Hydrochloride
CAS No.	123932-43-4
Molecular Formula	C26H39ClN2O4
Molecular Weight	479.05 g/mol
Synonyms	(R)-Norverapamil HCl; (R)-(+)-Norverapamil HCl; (R)-5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride; (R)-D617 Hydrochloride; (R)-Verapamil Metabolite D617 Hydrochloride; (2R)-2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino]-2-(1-methylethyl)pentanenitrile Hydrochloride; (R)-Norverapamil Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-(+)-Norverapamil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.