Description

(S)-(-)-Norverapamil Hydrochloride is a high-purity, single-enantiomer pharmaceutical intermediate and reference standard. This compound is a key chiral building block in advanced pharmaceutical research and development, particularly for studying calcium channel modulation. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise stereochemical control for developing novel therapeutics or analytical methods.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of advanced verapamil analogs and other calcium channel blockers.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical laboratories.
• Biochemical Research: Employed in pharmacological studies to investigate the stereospecific effects of calcium channel inhibition on cellular processes.
• Active Pharmaceutical Ingredient (API) Development: Serves as a starting material for the R&D of new enantiomerically pure drug candidates targeting cardiovascular and other conditions.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic pathway research related to verapamil.

Basic Information

Product Name	(S)-(-)-Norverapamil Hydrochloride
CAS No.	123931-31-7
Molecular Formula	C26H39ClN2O4
Molecular Weight	479.05 g/mol
Synonyms	(S)-Norverapamil HCl; (S)-5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride; (S)-Verapamil Impurity C; (S)-D-617 Hydrochloride; (S)-α-Isopropyl-α-[(N-methyl-N-homoveratryl)-γ-aminopropyl]-3,4-dimethoxyphenylacetonitrile Hydrochloride; (2S)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(-)-Norverapamil Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.