Description

Azelnidipine is a potent, long-acting dihydropyridine calcium channel blocker used primarily as an antihypertensive agent. Its high selectivity for vascular smooth muscle makes it a valuable active pharmaceutical ingredient (API) for developing cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on creating treatments for hypertension and related cardiovascular disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive drug formulations.
• Cardiovascular Research: A key reference standard and tool compound for studying calcium channel mechanisms and vascular physiology.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of azelnidipine-based medications.
• Analytical Development: Serves as a high-purity standard for HPLC, LC-MS, and other analytical method development and validation.
• Preclinical Studies: Used in pharmacological and toxicological evaluations during drug discovery and development stages.
• Combination Therapies: Potential component in fixed-dose combination drugs for managing hypertension and angina.

Basic Information

Product Name	Azelnidipine
CAS No.	123524-52-7
Molecular Formula	C33H34N4O6
Molecular Weight	582.65 g/mol
Synonyms	Azelnidipine; CS-905; 3-(1-Diphenylmethylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (RS)-Azelnidipine; (±)-Azelnidipine; Calblock; Azelnidipinum; Azelnidipino
EINECS	Contact for details

Quality Control

Our Azelnidipine is manufactured under strict quality management systems, ensuring it meets the high-purity standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via HPLC and related substances methods. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.