Description

Imidapril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension and heart failure. This active pharmaceutical ingredient (API) is valued for its efficacy in lowering blood pressure and reducing cardiovascular strain. It is primarily required by pharmaceutical manufacturers for the formulation of prescription medications. Imidapril CAS NO 120294-10-2 represents a critical component in the production of high-quality cardiovascular therapies.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and heart failure medications.
• Tablet Formulation: Incorporated into solid oral dosage forms for patient administration.
• Cardiovascular Drug Synthesis: Serves as a key intermediate or final compound in the synthesis of ACE inhibitor drugs.
• Clinical Research: Used in preclinical and clinical studies for cardiovascular disease research.
• Generic Drug Manufacturing: Essential for companies producing generic versions of branded imidapril medications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for drug production.

Basic Information

Product Name	Imidapril
CAS No.	120294-10-2
Molecular Formula	C20H27N3O6
Molecular Weight	405.45 g/mol
Synonyms	Imidapril Hydrochloride; (4S)-3-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid; Tanatril®; Novarok; Acemin; Cilazapril Impurity C; N-[(S)-1-Carboxy-3-phenylpropyl]-L-Ala-L-Pro Monohydrate; (S)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]hexahydro-2-oxo-1H-azepine-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Imidapril is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Quality is assured through comprehensive analytical testing, including HPLC for purity and identity confirmation. We provide full traceability and support regulatory submissions with detailed documentation. Certificates of Analysis (COA) are available for every batch, confirming compliance with in-house specifications and relevant pharmacopeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions with low humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Specific Rotation	-55.0° to -60.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.