Description

Imidaprilat is the active diacid metabolite of the prodrug antihypertensive agent, Imidapril. This compound is a potent and selective angiotensin-converting enzyme (ACE) inhibitor, making it a critical intermediate and reference standard in pharmaceutical research and development. It is essential for analytical method development, quality control, and pharmacological studies within the pharmaceutical industry. Professionals in pharmaceutical R&D, quality assurance laboratories, and fine chemical synthesis require high-purity Imidaprilat CAS NO 120294-09-9 to ensure the efficacy and safety of cardiovascular medications.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of Imidapril and related drug products via HPLC, LC-MS, and other analytical techniques.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the manufacturing process of Imidapril hydrochloride and other ACE inhibitor drugs.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the mechanism of action, pharmacokinetics, and metabolism of ACE inhibitors.
• Quality Control & Assurance: Critical for validating analytical methods and ensuring batch-to-batch consistency in pharmaceutical production under GMP guidelines.
• Metabolite Studies: Used in clinical and pre-clinical research to understand the biotransformation and activity profile of the parent drug.

Basic Information

Product Name	Imidaprilat
CAS No.	120294-09-9
Molecular Formula	C20H26N2O5
Molecular Weight	374.43 g/mol
Synonyms	(4S)-3-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid; (S)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]hexahydro-2-oxo-1H-azepine-4-carboxylic acid; Imidapril Diacid; Imidaprilat Diacid; TA-6366 (Diacid); ACE Inhibitor Diacid Metabolite
EINECS	Contact for details

Quality Control

Our Imidaprilat is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC, and control of specific impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development under cGMP and ICH Q7 guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.