Description

Manidipine Hydrochloride CAS NO 119992-99-3 is a high-purity pharmaceutical active ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the research, development, and manufacturing of antihypertensive medications, offering precise control over cardiovascular activity. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug formulation and advanced pharmacological studies.

Application

• Pharmaceutical API Manufacturing: Primary active ingredient in the commercial production of antihypertensive and antianginal drugs.
• Formulation R&D: Used in developing new dosage forms such as tablets, capsules, and controlled-release formulations.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in QC/QA laboratories.
• Clinical Research: Employed in preclinical and clinical studies to investigate efficacy, pharmacokinetics, and new therapeutic indications.
• Generic Drug Production: Essential for manufacturing bioequivalent generic versions of branded calcium channel blocker medications.
• Biochemical Research: Tool compound for studying calcium ion (Ca²⁺) channel physiology and vascular smooth muscle function in academic settings.

Basic Information

Product Name	Manidipine Hydrochloride
CAS No.	119992-99-3
Molecular Formula	C₃₅H₃₈N₄O₆•HCl
Molecular Weight	647.16 g/mol
Synonyms	Manidipine HCl; (±)-Manidipine Hydrochloride; 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride; Calslot; Manyper; CV-4093; CV 4093 hydrochloride; Franidipine Hydrochloride (obsolete)
EINECS	Contact for details

Quality Control

Our Manidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment to guarantee traceability and compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.2%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.