Description

(R)-Felodipine CAS NO 119945-59-4 is the single enantiomer of the widely used calcium channel blocker felodipine, offering a high-purity standard for advanced pharmaceutical research and development. This compound is critical for studying stereospecific drug action, metabolism, and for the development of novel enantiopure cardiovascular therapeutics. It is an essential building block for medicinal chemists, pharmacologists, and analytical scientists focused on chiral separation and the development of next-generation antihypertensive agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, assay, and impurity profiling of felodipine in pharmacopeial testing (USP/EP).
• Chiral Drug Development: Used as a key intermediate in the research and synthesis of enantiomerically pure cardiovascular drugs to study efficacy and reduce side effects.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo studies to investigate the stereoselective absorption, distribution, metabolism, and excretion (ADME) of felodipine.
• Analytical Method Development: Essential for developing and validating chiral HPLC or SFC methods for the separation of felodipine enantiomers.
• Biochemical Research: Used as a tool compound to study the specific interaction of the (R)-enantiomer with L-type calcium channels and other biological targets.

Basic Information

Product Name	(R)-Felodipine
CAS No.	119945-59-4
Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.25 g/mol
Synonyms	(R)-Felodipine; (R)-3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (R)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester; Dexfelodipine; (R)-Plendil; (R)-Splendil; Felodipine Impurity C (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-Felodipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess. We support compliance with cGMP and ISO guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.