Description

Niguldipine Hydrochloride is a high-purity calcium channel blocker compound, specifically a dihydropyridine derivative, offered as a hydrochloride salt for enhanced stability and handling. This product is a critical pharmaceutical reference standard and active pharmaceutical ingredient (API) intermediate used in cardiovascular research and drug development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic research sectors focusing on hypertension, angina, and related cardiovascular disorders.

Application

• Pharmaceutical R&D: Serves as a key reference standard and intermediate in the synthesis and development of novel calcium channel blockers.
• Biochemical Research: Used as a potent and selective tool compound to study L-type calcium channels and their role in vascular smooth muscle and cardiac tissue.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate mechanisms of vasodilation and cardiovascular pharmacology.
• Analytical Method Development: Acts as a certified reference material (CRM) for HPLC, LC-MS, and other analytical techniques to ensure method accuracy and validation.
• GMP/GLP Manufacturing: Used as a starting material or intermediate in the controlled synthesis of active pharmaceutical ingredients under quality-managed environments.

Basic Information

Product Name	Niguldipine Hydrochloride
CAS No.	119934-51-9
Molecular Formula	C28H31ClN2O6
Molecular Weight	527.01 g/mol
Synonyms	Niguldipine HCl; BAY a 7168; (RS)-Niguldipine hydrochloride; 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester hydrochloride; 5-O-Methylniguldipine hydrochloride; BAY a7168; BAY-a 7168; BAY-a7168
EINECS	Contact for details

Quality Control

Our Niguldipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, reporting results from advanced techniques including HPLC, NMR, and mass spectrometry. We support compliance with ICH guidelines and can supply material suitable for research and development applications under current Good Manufacturing Practice (cGMP) principles upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.