Description

Iganidipine is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. Its primary value lies in its critical role in the research, development, and manufacturing of advanced cardiovascular therapeutics. This compound is essential for pharmaceutical companies, R&D laboratories, and academic institutions focused on creating new drug formulations and conducting pharmacological studies.

Application

• Pharmaceutical API Synthesis: Primary intermediate in the production of finished dosage forms for cardiovascular medications.
• Research & Development: Key reference standard and building block for pharmacological studies and new drug discovery programs targeting hypertension and angina.
• Analytical Standard: Used as a certified reference material (CRM) for method development, validation, and quality control testing in analytical laboratories.
• Preclinical Studies: Employed in bioavailability, pharmacokinetic, and toxicology research to assess drug efficacy and safety profiles.
• Process Chemistry: Serves as a crucial intermediate for scaling up synthesis under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	Iganidipine
CAS No.	119687-33-1
Molecular Formula	C27H28N2O6
Molecular Weight	476.52 g/mol
Synonyms	Iganidipine; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[N-benzyl-N-(methylsulfonyl)amino]ethyl] ester 5-methyl ester; FRC-8653; CAS 119687-33-1; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-[2-[(phenylmethyl)methylsulfonyl)amino]ethyl] methyl ester
EINECS	Contact for details

Quality Control

Our Iganidipine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to meet stringent pharmaceutical-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.