Description

Lifarizine is a selective calcium channel blocker belonging to the piperazine chemical class. This compound is significant for its neuroprotective properties and its role in modulating cellular calcium influx, which is crucial for research into neurological conditions. It is primarily utilized by pharmaceutical R&D teams and academic researchers investigating pathways related to ischemia, arrhythmias, and other calcium-mediated cellular dysfunctions. Lifarizine CAS NO 119514-66-8 represents a high-purity research chemical for advanced pharmacological studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of neuroprotective and cardioprotective agents.
• Neurological Disorder Studies: Used in preclinical research to investigate mechanisms of action in models of cerebral ischemia, stroke, and neurodegenerative diseases.
• Cardiovascular Research: Employed as a tool compound to study L-type calcium channel blockade and its effects on cardiac arrhythmias and muscle contraction.
• Cellular Biology: Applied in *in vitro* assays to study calcium signaling pathways, apoptosis, and cellular excitability.
• Chemical Synthesis: Acts as a sophisticated building block or precursor for the synthesis of novel therapeutic compounds and analogs.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental pharmacological and biochemical studies.

Basic Information

Product Name	Lifarizine
CAS No.	119514-66-8
Molecular Formula	C20H21FN2O2
Molecular Weight	340.40 g/mol
Synonyms	1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine; McN-5691; McN 5691; RS-87476; RS 87476; (4-Fluorophenyl)[4-[(2,3,4-trimethoxyphenyl)methyl]-1-piperazinyl]methanone; Lifarizine Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Lifarizine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.