Description

Benidipine is a potent and selective dihydropyridine-class calcium channel blocker used primarily in pharmaceutical research and development. This compound is valued for its high specificity in modulating L-type calcium channels, which is critical for studying cardiovascular physiology and developing new therapeutic agents. It is an essential intermediate and reference standard for researchers and manufacturers in the pharmaceutical industry focusing on hypertension and angina treatment pathways.

Application

• Primary active pharmaceutical ingredient (API) in antihypertensive medication formulations.
• Critical reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Key intermediate in the synthesis of advanced cardiovascular drug candidates.
• Used in preclinical and clinical research to study calcium channel blocker mechanisms and efficacy.
• Essential material for pharmacokinetic and pharmacodynamic studies in drug discovery.
• Component in the development of combination therapies for cardiovascular diseases.

Basic Information

Product Name	Benidipine
CAS No.	119065-61-1
Molecular Formula	C28H31N3O6
Molecular Weight	505.56 g/mol
Synonyms	Benidipine Hydrochloride; KW-3049; Coniel; 3-[(3R)-1-Benzyl-3-piperidinyl] 5-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (±)-Benidipine; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(phenylmethyl)-3-piperidinyl] ester 5-methyl ester
EINECS	Contact for details

Quality Control

Our Benidipine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material that meets in-house specifications aligned with industry standards for advanced intermediates and reference compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.