Description

Benidipine is a potent and highly selective dihydropyridine-class calcium channel blocker (CCB). This compound is a critical active pharmaceutical ingredient (API) valued for its long-lasting antihypertensive and antianginal effects. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of cardiovascular medications. Benidipine CAS NO 119009-45-9 is essential for formulators requiring a high-purity, reliable API for advanced therapeutic applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive and antianginal drug formulations.
• Cardiovascular Research: A key reference standard and tool compound for studying L-type and T-type calcium channel inhibition.
• Drug Development: Used in preclinical and clinical research for developing new cardiovascular therapies with improved vascular selectivity.
• Generic Medicine Production: Sourcing for the manufacture of generic versions of benidipine-based medications.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Combination Therapies: Potential use in fixed-dose combination drugs targeting hypertension and related conditions.

Basic Information

Product Name	Benidipine
CAS No.	119009-45-9
Molecular Formula	C28H31N3O6
Molecular Weight	505.57 g/mol
Synonyms	Benidipine Hydrochloride; KW-3049; Coniel; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl] ester 5-methyl ester; (±)-Benidipine; (RS)-Benidipine; FRC-8653
EINECS	Contact for details

Quality Control

Our Benidipine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and GC, to ensure it meets high-purity pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.