Description

Nexopamil (Racemate) is a calcium channel blocker of the benzothiazepine class, primarily used as a key pharmaceutical intermediate. Its significance lies in its role in the synthesis of active pharmaceutical ingredients (APIs) for cardiovascular research and development. This compound is essential for manufacturers and research institutions focused on developing novel therapeutic agents for hypertension and angina. The product is supplied as the racemic mixture, CAS NO 116759-35-4.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced calcium channel blocker APIs.
• Cardiovascular Research: Critical building block for preclinical and clinical research into new cardiovascular drugs.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Process Development: Used in scaling up and optimizing synthetic routes for commercial drug manufacturing.
• Academic & Institutional Research: Employed in pharmacological studies to investigate calcium channel mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Nexopamil (Racemate)
CAS No.	116759-35-4
Molecular Formula	C26H26N2O4S
Molecular Weight	462.56 g/mol
Synonyms	(±)-Nexopamil; rac-Nexopamil; Nexopamil Racemic Mixture; 1,5-Benzothiazepine derivative; 4-[2-(3,4-Dimethoxyphenyl)ethyl]-α-phenyl-2-(1-piperazinyl)-3(2H)-isoquinolinone; (RS)-Nexopamil; Benzothiazepine calcium antagonist
EINECS	Contact for details

Quality Control

Our Nexopamil (Racemate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets exacting standards for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.