Description

Mibefradil CAS NO 116666-63-8 is a selective T-type calcium channel blocker of significant pharmaceutical interest. This compound is a key intermediate and reference standard in cardiovascular research and drug development. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and intermediate in the synthesis and study of novel calcium channel blockers.
• Analytical Chemistry: Used as a high-purity certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and NMR analyses.
• Preclinical Studies: Employed in pharmacological research to investigate T-type calcium channel mechanisms in cardiovascular and neurological models.
• Chemical Synthesis: Acts as a building block for the preparation of structurally related analogs and derivatives for structure-activity relationship (SAR) studies.
• Academic Research: Utilized in university and institutional labs for biochemical and physiological research projects.
• Regulatory Compliance: Provides a qualified standard for impurity identification and characterization to meet ICH guidelines for pharmaceutical submissions.

Basic Information

Product Name	Mibefradil
CAS No.	116666-63-8
Molecular Formula	C29H38FN3O3
Molecular Weight	495.63 g/mol
Synonyms	Mibefradil; (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate; Ro 40-5967; Posicor; (+)-Mibefradil; (1S,2S)-Mibefradil; Mibefradil dihydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Mibefradil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.