Description

Mibefradil Dihydrochloride CAS NO 116644-53-2 is a high-purity pharmaceutical intermediate and research chemical, specifically the dihydrochloride salt of the calcium channel blocker mibefradil. This compound is of significant interest for its role in cardiovascular research and the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for synthesis and pharmacological studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of the calcium channel antagonist Mibefradil.
• Cardiovascular Research: Used in preclinical and biochemical studies to investigate T-type calcium channel blockade and its effects on heart rate and vascular tone.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Mechanistic Studies: Employed in vitro and in vivo to study calcium signaling pathways and their implications in various disease models.
• API Manufacturing: Used in the controlled production of the finished active pharmaceutical ingredient under current Good Manufacturing Practices (cGMP).

Basic Information

Product Name	Mibefradil Dihydrochloride
CAS No.	116644-53-2
Molecular Formula	C29H38N2O3 · 2HCl
Molecular Weight	539.54 g/mol
Synonyms	Mibefradil HCl; Mibefradil Dihydrochloride; (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride; Ro 40-5967; Posicor (as base); CAS 116644-53-2
EINECS	Contact for details

Quality Control

Our Mibefradil Dihydrochloride is manufactured and tested to meet stringent quality standards suitable for research and pharmaceutical applications. Every batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and NMR. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.