Description

Semotiadil is a potent calcium channel blocker belonging to the benzothiazepine class of pharmaceutical compounds. This high-purity active pharmaceutical ingredient (API) is critical for the research and development of novel cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions focused on hypertension, angina, and other cardiac conditions. Our supply ensures consistent quality and reliable availability for critical development and production processes.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced cardiovascular drug formulations.
• Cardiovascular Research: Used as a reference standard and active compound in preclinical studies investigating calcium channel modulation.
• Analytical Standard: Employed in quality control laboratories for method development, validation, and assay calibration (HPLC, GC).
• Mechanistic Studies: Applied in biochemical research to study the effects of calcium influx inhibition on vascular smooth muscle and cardiac tissue.
• Formulation Development: Utilized in the development of dosage forms such as tablets or capsules during drug product R&D.

Basic Information

Product Name	Semotiadil
CAS No.	116476-13-2
Molecular Formula	C21H28N2O4S2
Molecular Weight	436.59 g/mol
Synonyms	Semotiadil; 116476-13-2; (+)-Semotiadil; (3R,4S)-Semotiadil; SD-3211; SD 3211; SD3211; 4-[2-[(3,4-Dimethoxyphenethyl)methylamino]ethyl]-5-sulfamoyl-2,3-dihydro-1,2-benzisothiazole 1,1-Dioxide; 1,2-Benzisothiazole, 4-[2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]ethyl]-5-(aminosulfonyl)-2,3-dihydro-, 1,1-dioxide, (3R,4S)-
EINECS	Contact for details

Quality Control

Our Semotiadil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided, documenting identity, purity, and impurity profiles as determined by HPLC, IR, and other pharmacopeial methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.