Description

Cronidipine CAS NO 113759-50-5 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical building block in the research and development of novel cardiovascular therapeutics targeting hypertension and angina. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in drug discovery and synthesis.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient in the formulation of calcium channel blocker medications.
• Cardiovascular Drug Research: Key intermediate in the R&D of new antihypertensive and antianginal drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Used in pharmacological studies to investigate calcium channel mechanisms and vascular smooth muscle function.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for dihydropyridine derivatives.

Basic Information

Product Name	Cronidipine
CAS No.	113759-50-5
Molecular Formula	C20H23N3O6
Molecular Weight	401.41 g/mol
Synonyms	CRD; Cronidipine; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester; (±)-Cronidipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[benzyl(methyl)amino]ethyl] 5-methyl ester
EINECS	Contact for details

Quality Control

Our Cronidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.