Description

(+/-)-Niguldipine Hydrochloride CAS NO 113317-61-6 is a high-purity calcium channel blocker compound, primarily recognized for its potent pharmacological research applications. This material is critical for advancing studies in cardiovascular physiology and drug discovery due to its specific inhibitory action on L-type calcium channels. It is an essential reference standard and key intermediate for pharmaceutical R&D laboratories, academic research institutions, and analytical testing facilities focused on developing new therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used for method development, validation, and quality control in analytical laboratories (HPLC, LC-MS).
• Biochemical Research: A key tool compound for studying calcium channel function and signal transduction pathways in cardiovascular and neurological systems.
• Drug Discovery & Development: Serves as a crucial intermediate or active pharmaceutical ingredient (API) precursor in the synthesis of novel calcium channel blockers.
• Pharmacological Screening: Employed in high-throughput screening assays to identify and characterize new drug candidates targeting hypertension and angina.
• Academic Research: Utilized in university and institutional labs for fundamental research on vascular smooth muscle contraction and cardiac electrophysiology.
• Impurity Profiling: Acts as a known impurity or degradation product marker in the analysis of related dihydropyridine pharmaceuticals.

Basic Information

Product Name	(+/-)-Niguldipine Hydrochloride
CAS No.	113317-61-6
Molecular Formula	C28H33N3O6·HCl
Molecular Weight	544.04 g/mol
Synonyms	Niguldipine HCl; BAY w 6220; BAY w-6220; BAY w6220; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(2-benzhydryloxy)ethyl] 5-(1-methylethyl) ester hydrochloride; (±)-Niguldipine hydrochloride; UNII-7J5X2W29J6; 7J5X2W29J6
EINECS	Contact for details

Quality Control

Our (+/-)-Niguldipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with complete batch data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive; prolonged exposure should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.