Description

S(+)-Niguldipine Hydrochloride is the pharmacologically active enantiomer of the dihydropyridine calcium channel blocker niguldipine. This high-purity chiral compound is essential for advanced pharmaceutical research and development, particularly in studying receptor selectivity and metabolic pathways. It is primarily utilized by medicinal chemists and pharmacologists in the pharmaceutical and biotechnology industries for preclinical studies, analytical method development, and as a reference standard.

Application

• Pharmaceutical R&D Reference Standard: Serves as a critical chiral reference material for method development, validation, and quality control in the synthesis of enantiomerically pure drugs.
• Mechanistic & Pharmacological Studies: Used to investigate the specific biological activity, receptor binding, and metabolic profile of the S-enantiomer separate from its racemic mixture or R-enantiomer.
• Calcium Channel Research: A key tool compound for studying L-type calcium channel blockade and its effects in cardiovascular and neurological research models.
• Process Chemistry & Analytical Development: Employed in developing and optimizing chiral separation techniques, such as HPLC or SFC, for pharmaceutical analysis.
• Impurity Identification & Characterization: Acts as a known impurity standard in the quality control of bulk drug substances and finished dosage forms containing related dihydropyridine compounds.

Basic Information

Product Name	S(+)-Niguldipine Hydrochloride
CAS No.	113165-32-5
Molecular Formula	C28H33ClN2O6
Molecular Weight	529.02 g/mol
Synonyms	(+)-Niguldipine hydrochloride; (S)-Niguldipine hydrochloride; BAY K 5552; BAY-K-5552; (S)-(-)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(2-(diphenylmethyl)-1-azetidinyl)ethyl] methyl ester hydrochloride; S-(-)-Niguldipine hydrochloride; (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[2-(benzhydryl)azetidin-1-yl]ethyl methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our S(+)-Niguldipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and chiral excess is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.