Description

R(-)-Niguldipine Hcl is a high-purity enantiomer of the dihydropyridine calcium channel blocker niguldipine. This compound is a critical chiral intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies for investigating cardiovascular pharmacology and developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Research: Serves as a selective tool compound for studying L-type calcium channels and their role in cellular signaling pathways.
• Preclinical Development: Employed as a key chiral building block or intermediate in the synthesis of potential new chemical entities (NCEs) targeting cardiovascular diseases.
• Metabolite Studies: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) research to understand the pharmacokinetic profile of niguldipine and related analogs.
• Enantiomeric Purity Analysis: Acts as a pure enantiomer for calibrating chiral separation methods like HPLC and SFC to assess the optical purity of synthesized compounds.

Basic Information

Item	Detail
Product Name	R(-)-Niguldipine Hydrochloride
CAS No.	113145-70-3
Molecular Formula	C28H33N3O6 • HCl
Molecular Weight	544.04 g/mol
Synonyms	(-)-Niguldipine hydrochloride; (R)-Niguldipine hydrochloride; B 859-35; BAY w 9798; (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride; Niguldipine (R)-enantiomer hydrochloride; (R)-(-)-Niguldipine HCl
EINECS	Contact for details

Quality Control

Our R(-)-Niguldipine Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.