Description

(S)-(+)-Niguldipine Hydrochloride is the single enantiomer of the dihydropyridine calcium channel blocker niguldipine. This high-purity enantiomer is critical for advanced pharmacological research and development, offering a precise tool for studying stereospecific drug-receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers focused on cardiovascular drug discovery, enantioselective synthesis, and receptor binding studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Cardiovascular Research: Used as a selective research chemical to investigate L-type calcium channel blockade and its effects on vascular smooth muscle and cardiac tissue.
• Enantioselective Pharmacology Studies: Essential for comparative studies against its (R)-(-) enantiomer to elucidate stereospecific pharmacokinetics, metabolism, and therapeutic efficacy.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays and receptor binding studies to identify and characterize new drug candidates.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental studies in medicinal chemistry and molecular pharmacology.
• Process Chemistry & Synthesis: Used as a chiral intermediate or building block in the asymmetric synthesis of more complex pharmaceutical compounds.

Basic Information

Product Name	(S)-(+)-Niguldipine Hydrochloride
CAS No.	113145-69-0
Molecular Formula	C28H33ClN2O6
Molecular Weight	529.02 g/mol
Synonyms	(S)-Niguldipine HCl; (S)-(+)-Niguldipine HCl; (S)-B859-35; (S)-3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[4-(diphenylmethyl)-1-piperazinyl]propyl 5-methyl ester, hydrochloride, (S)-; (+)-Niguldipine hydrochloride; BAY w 9768 (S-enantiomer); (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[4-(diphenylmethyl)-1-piperazinyl]propyl 5-methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(+)-Niguldipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet exacting standards for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.