Description

Clentiazem is a potent calcium channel blocker belonging to the benzothiazepine class, structurally related to diltiazem. This compound is of significant interest in pharmaceutical research and development for its potential cardiovascular applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and the study of calcium channel modulation.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel calcium channel antagonists.
• Biochemical Research: Used as a reference standard or active compound in pharmacological studies investigating ion channel function.
• Preclinical Development: Serves as a candidate molecule for evaluating efficacy and safety profiles in animal models for cardiovascular diseases.
• Mechanistic Studies: Employed to understand the structure-activity relationship (SAR) within the benzothiazepine class of drugs.

Basic Information

Product Name	Clentiazem
CAS No.	111659-76-8
Molecular Formula	C19H23N3O4S2
Molecular Weight	421.53 g/mol
Synonyms	Clentiazem; TA-3090; (2S,3S)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-3-(phenylcarbamoyl)-1,5-benzothiazepin-4(5H)-one 1,1-Dioxide; 1,5-Benzothiazepin-4(5H)-one, 5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-3-[(phenylamino)carbonyl]-, 1,1-dioxide, (2S,3S)-
EINECS	Contact for details

Quality Control

Our Clentiazem is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced analytical techniques such as HPLC, NMR, and mass spectrometry. We support research and development with material that meets stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.