Description

Efonidipine Hydrochloride CAS NO 111011-79-1 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is critical for the research, development, and manufacturing of antihypertensive and antianginal medications. This compound is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery and production.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the commercial production of antihypertensive drugs.
• Cardiovascular Research: A key reference standard and tool compound for studying L-type and T-type calcium channel inhibition.
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules.
• Process Chemistry & Scale-up: Serves as a critical intermediate for process optimization and pilot-scale manufacturing.
• Analytical Method Development: Employed as a high-purity standard for HPLC, LC-MS, and other analytical techniques.
• Regulatory Submissions: Supplied as a qualified material for use in stability studies and regulatory filing dossiers (e.g., DMF, CMC sections).

Basic Information

Product Name	Efonidipine Hydrochloride
CAS No.	111011-79-1
Molecular Formula	C34H39N3O6•HCl
Molecular Weight	614.15 g/mol
Synonyms	Efonidipine HCl; NZ-105; (±)-Efonidipine Hydrochloride; 2-[2-[N-Benzyl-N-(3,4-dimethoxyphenethyl)amino]ethyl] 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-3-pyridinecarboxylate Hydrochloride; 1,4-Dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-5-nitro-3-pyridinecarboxylic acid 2-[N-benzyl-N-[2-(3,4-dimethoxyphenyl)ethyl]amino]ethyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our Efonidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.