Description

Efonidipine is a dihydropyridine calcium channel blocker used as a key active pharmaceutical ingredient (API). This compound is valued for its specific pharmacological activity in managing hypertension and related cardiovascular conditions. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of cardiovascular medications.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in antihypertensive drug formulations.
• Research and development of novel cardiovascular therapeutics targeting calcium channels.
• Manufacturing of finished dosage forms such as tablets and capsules for clinical use.
• Reference standard in analytical laboratories for quality control and method validation.
• Preclinical and clinical studies investigating its mechanism of action and efficacy.
• Potential use in combination drug therapies for enhanced treatment of hypertension.

Basic Information

Product Name	Efonidipine
CAS No.	111011-76-8
Molecular Formula	C34H39N3O6
Molecular Weight	585.69 g/mol
Synonyms	NZ-105; Efonidipine Hydrochloride; Ethyl 5-(5,5-Dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; 2-[4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate]ethyl 5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane; (±)-Efonidipine; (RS)-Efonidipine; Landel
EINECS	Contact for details

Quality Control

Our Efonidipine is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory compliance and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.