Description

Efonidipine is a dihydropyridine calcium channel blocker used as an active pharmaceutical ingredient (API). This compound is significant for its role in the development and manufacture of antihypertensive medications, offering a mechanism to manage high blood pressure. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) involved in cardiovascular drug production and advanced pharmacological research.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in antihypertensive drug formulations.
• Key component in cardiovascular research for studying calcium channel mechanisms.
• Reference standard in analytical method development and quality control laboratories.
• Starting material or intermediate for the synthesis of novel pharmaceutical derivatives.
• Used in preclinical and clinical studies to evaluate pharmacokinetics and efficacy.

Basic Information

Product Name	Efonidipine
CAS No.	111011-63-3
Molecular Formula	C34H39N3O6
Molecular Weight	585.70 g/mol
Synonyms	NZ-105; (±)-Efonidipine; Ethyl 5-(5,5-Dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; 2-[4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate] 5,5-dimethyl-1,3,2λ⁵-dioxaphosphorinane 2-oxide; Ethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-[(5,5-dimethyl-2-oxido-1,3,2λ⁵-dioxaphosphorinan-2-yl)]-1,4-dihydropyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our Efonidipine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength, meeting high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing specific results for assay, related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.