Description

Efonidipine Hcl CAS NO 111011-53-1 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the research, development, and manufacturing of next-generation antihypertensive and cardiovascular medications. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and API producers focused on innovative drug formulations.

Application

• Pharmaceutical API Synthesis: Key intermediate in the production of Efonidipine hydrochloride ethanolate, the active pharmaceutical ingredient.
• Cardiovascular Drug R&D: Used in preclinical and clinical research for developing new calcium channel blockers for hypertension and angina.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.
• Process Chemistry: Employed in route scouting, optimization, and scale-up studies for efficient API manufacturing processes.
• Academic Research: Utilized in university and institutional studies investigating the structure-activity relationships of dihydropyridine derivatives.

Basic Information

Product Name	Efonidipine Hcl
CAS No.	111011-53-1
Molecular Formula	C34H39N3O6•HCl
Molecular Weight	622.15 g/mol (for free base C34H39N3O6)
Synonyms	Efonidipine Hydrochloride; NZ-105; (±)-Efonidipine Hydrochloride; 2-[2-[N-Benzyl-N-(3,4-dimethoxyphenethyl)amino]ethyl] 1,4-dihydro-2,6-dimethyl-5-nitro-4-(3-nitrophenyl)-3-pyridinecarboxylate Hydrochloride; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-nitro-3-pyridinecarboxylic Acid 2-[N-Benzyl-N-[2-(3,4-dimethoxyphenyl)ethyl]amino]ethyl Ester Hydrochloride; Ethyl 4-(3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative HCl
EINECS	Contact for details

Quality Control

Our Efonidipine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, consistency, and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.