Description

Tiamdipine is a high-purity pharmaceutical intermediate and research chemical belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the development and synthesis of advanced cardiovascular therapeutics, offering a key building block for targeted drug formulations. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and academic research institutions focused on hypertension and angina treatment pathways.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: A key intermediate in the production of calcium channel blocker medications.
• Cardiovascular Research: Used in preclinical and clinical studies to investigate mechanisms for treating hypertension and angina.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical laboratories.
• Biochemical Studies: Employed in pharmacological assays to study vascular smooth muscle and cardiac cell function.
• Process Development: Utilized in scaling up and optimizing synthetic routes for dihydropyridine-based drugs.

Basic Information

Item	Details
Product Name	Tiamdipine
CAS No.	110646-15-6
Molecular Formula	C21H23N3O6S
Molecular Weight	445.49 g/mol
Synonyms	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-methylethyl ester; Tiamdipinum; Tiamdipino; (±)-Tiamdipine; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid isopropyl methyl ester
EINECS	Contact for details

Quality Control

Our Tiamdipine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.