Description

Temocaprilat CAS NO 110221-53-9 is the active diacid metabolite of the prodrug Temocapril, functioning as a potent and long-acting angiotensin-converting enzyme (ACE) inhibitor. This compound is of significant value in pharmaceutical research and development for its role in studying cardiovascular pharmacology and hypertension mechanisms. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of novel antihypertensive agents and metabolic studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A critical synthetic precursor in the production of Temocapril and related prodrug formulations.
• Biochemical Research: Used in in vitro and in vivo studies to investigate ACE inhibition kinetics, structure-activity relationships (SAR), and cardiovascular disease pathways.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic (PK/PD) profiling to understand the biotransformation and efficacy of Temocapril.
• Analytical Method Development: Employed as a high-purity standard for calibrating HPLC, LC-MS, and other chromatographic systems in bioanalytical laboratories.

Basic Information

Product Name	Temocaprilat
CAS No.	110221-53-9
Molecular Formula	C23H28N2O5S2
Molecular Weight	476.61 g/mol
Synonyms	(2S)-1-[(2S)-6-Methoxy-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxohexyl]pyrrolidine-2-carboxylic acid; Temocapril diacid; Temocaprilat diacid; Temocapril metabolite; ACE inhibitor metabolite; (S)-Temocaprilat; CS-622
EINECS	Contact for details

Quality Control

Our Temocaprilat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.