Description

Temocapril Hydrochloride CAS NO 110221-44-8 is a high-purity active pharmaceutical ingredient (API) belonging to the class of angiotensin-converting enzyme (ACE) inhibitors. This compound is critical for pharmaceutical research and development, particularly in the study of cardiovascular therapeutics. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in the development of novel antihypertensive drugs and related formulations.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of antihypertensive and cardiovascular medications.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Biochemical Research: A key tool for studying the mechanism of action of ACE inhibitors and their effects on the renin-angiotensin system.
• Preclinical Studies: Employed in pharmacological and toxicological evaluations during the drug discovery and development process.
• Process Development: Serves as a benchmark in the development and optimization of synthetic routes for scale-up manufacturing.

Basic Information

Product Name	Temocapril Hydrochloride
CAS No.	110221-44-8
Molecular Formula	C23H28N2O5S2 • HCl
Molecular Weight	529.07 g/mol
Synonyms	Temocapril HCl; (2S,6R)-6-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino-5-oxo-2-(2-thienyl)perhydro-1,4-thiazepine-4-acetic acid hydrochloride; Temocapril Hydrochloride Hydrate; CS-622; Alacepril metabolite; ACE Inhibitor CS-622
EINECS	Contact for details

Quality Control

Our Temocapril Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.