Description

(S)-Nilvadipine CAS NO 109545-30-4 is the pharmacologically active enantiomer of the dihydropyridine calcium channel blocker nilvadipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on producing advanced active pharmaceutical ingredients (APIs) with targeted therapeutic effects and reduced side-effect profiles.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure (S)-nilvadipine API.
• Cardiovascular Drug Research: Used in preclinical and clinical studies to investigate selective L-type calcium channel blockade.
• Chiral Catalyst & Ligand Development: Serves as a sophisticated precursor or model compound in asymmetric synthesis research.
• Reference Standard: Acts as a high-purity certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Metabolite Studies: Employed in the synthesis and identification of specific drug metabolites for pharmacokinetic profiling.
• Process Chemistry Optimization: Used to develop and scale up efficient, stereoselective synthetic routes for nilvadipine and related analogs.

Basic Information

Product Name	(S)-Nilvadipine
CAS No.	109545-30-4
Molecular Formula	C19H19N3O6
Molecular Weight	385.37 g/mol
Synonyms	(S)-Nilvadipine; (S)-2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester; (S)-3-Isobutyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (S)-Enantiomer of Nilvadipine; (-)-Nilvadipine; SC-66110 (S-form); FK-235 (S-form)
EINECS	Contact for details

Quality Control

Our (S)-Nilvadipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess determination, to ensure it meets the high-purity standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.