Description

(R)-Nilvadipine CAS NO 109545-29-1 is the single enantiomer of the dihydropyridine calcium channel blocker nilvadipine, representing a high-purity chiral building block of significant interest in advanced pharmaceutical research and development. This compound is critical for studying structure-activity relationships and developing enantiomerically pure therapeutics targeting cardiovascular diseases. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on chiral chemistry and drug discovery.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for method development and quality control of nilvadipine-based drug substances and products.
• Chiral Intermediate Synthesis: Used as a key enantiopure starting material or intermediate in the synthesis of novel, targeted calcium channel blockers and other chiral active pharmaceutical ingredients (APIs).
• Metabolic and Pharmacological Studies: Employed in preclinical research to investigate the distinct pharmacokinetic, pharmacodynamic, and metabolic profiles of the (R)-enantiomer separately from its (S)-counterpart.
• Analytical Method Development: Essential for developing and validating enantioselective analytical methods, such as chiral HPLC or SFC, to ensure the stereochemical purity of pharmaceutical compounds.
• Academic & Institutional Research: Supports fundamental research in medicinal chemistry, pharmacology, and stereochemistry at universities and government research institutes.

Basic Information

Product Name	(R)-Nilvadipine
CAS No.	109545-29-1
Molecular Formula	C19H19N3O6
Molecular Weight	385.37 g/mol
Synonyms	(R)-Nilvadipine; (R)-3-Methyl 5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (R)-(-)-Nilvadipine; (R)-Form of Nilvadipine; Dextro-Nilvadipine; (R)-Isomer of Nilvadipine; (R)-FK 235; ARC 029
EINECS	Contact for details

Quality Control

Our (R)-Nilvadipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing specifications such as chiral purity (by HPLC), chemical purity, and residual solvents are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.