Description

(S)-Felodipine is the single enantiomer of the dihydropyridine calcium channel blocker, felodipine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories, process chemists, and manufacturers specializing in advanced active pharmaceutical ingredients (APIs).

Application

• Key chiral building block for the synthesis of enantiopure felodipine API.
• Pharmacological research standard for studying the stereospecific activity of calcium channel blockers.
• Process development and optimization for asymmetric synthesis routes in pharmaceutical manufacturing.
• Reference material in analytical method development for chiral separation and purity assays.
• Starting material for the preparation of novel derivative compounds in medicinal chemistry.
• Critical intermediate in the production of high-value specialty pharmaceuticals targeting hypertension and angina.

Basic Information

Product Name	(S)-Felodipine
CAS No.	105618-03-9
Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.25 g/mol
Synonyms	(S)-Felodipine; (S)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester; (S)-3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (S)-Plendil; S-Felodipine; Felodipine S-enantiomer; (S)-(-)-Felodipine
EINECS	Contact for details

Quality Control

Our (S)-Felodipine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and identification, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting purity, enantiomeric excess, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.