Description

Barnidipine Hydrochloride is a high-purity pharmaceutical active ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. This compound is critical for the research and development of antihypertensive medications, offering a targeted mechanism of action for cardiovascular therapies. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in cardiovascular drug discovery and formulation.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of antihypertensive and antianginal medications.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Biochemical Research: A key tool for studying calcium channel physiology, vascular smooth muscle contraction, and mechanisms of vasodilation.
• Preclinical Studies: Employed in pharmacological and toxicological evaluations during the drug development pipeline.
• Generic Drug Manufacturing: Serves as the core component for producing generic versions of barnidipine-based therapeutics.

Basic Information

Item	Detail
Product Name	Barnidipine Hydrochloride
CAS No.	104831-94-9
Molecular Formula	C27H29N3O6 · HCl
Molecular Weight	528.00 g/mol
Synonyms	Barnidipine HCl; Mepirodipine Hydrochloride; YM-730; (R)-1-Benzyl-3-pyrrolidinyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride; (±)-Barnidipine Hydrochloride; CS-905; Hypoca; Nivadil
EINECS	Contact for details

Quality Control

Our Barnidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) providing results for identity, purity, and related substances is supplied with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.