Description

Barnidipine Hydrochloride CAS NO 104757-55-3 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is critical for the research, development, and production of antihypertensive medications, offering a targeted mechanism of action. This compound is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on cardiovascular therapeutics.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of antihypertensive and antianginal drugs.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical testing.
• Biomedical Research: Used in preclinical and clinical studies to investigate calcium channel modulation and vascular physiology.
• Process Development: Employed in the development and scale-up of synthetic routes for new drug formulations.
• Generic Drug Manufacturing: A key component in the production of generic versions of calcium channel blocker medications.

Basic Information

Product Name	Barnidipine Hydrochloride
CAS No.	104757-55-3
Molecular Formula	C27H29N3O6·HCl
Molecular Weight	528.00 g/mol
Synonyms	Barnidipine HCl; Mepirodipine Hydrochloride; YM-730; (±)-Barnidipine Hydrochloride; 3-(1-Benzyl-3-piperidinyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride; CY 216; CAS 104757-55-3
EINECS	Contact for details

Quality Control

Our Barnidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and impurities. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.