Description

Barnidipine Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) primarily used in antihypertensive drug formulations. Its value lies in its potent and selective calcium channel blocking activity, which is critical for the development of effective cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing treatments for hypertension and related cardiovascular conditions.

Application

• Active Pharmaceutical Ingredient (API) in finished antihypertensive drug products.
• Pharmaceutical Intermediate for the synthesis of advanced calcium channel blockers.
• Reference Standard for quality control and analytical method development in pharmaceutical labs.
• Research & Development of novel cardiovascular therapeutics and drug delivery systems.
• Pharmacological Studies investigating mechanisms of vascular smooth muscle relaxation.
• Formulation Development for tablets, capsules, and other oral dosage forms.

Basic Information

Product Name	Barnidipine Hydrochloride
CAS No.	104757-54-2
Molecular Formula	C27H29N3O6 • HCl
Molecular Weight	520.00 g/mol
Synonyms	Barnidipine HCl; Mepirodipine Hydrochloride; YM-09730-5; (±)-Barnidipine Hydrochloride; 1-Benzyl-3-(3-(N-benzyl-N-methylamino)propoxy)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride; CY 216; Nivadil (brand name reference)
EINECS	Contact for details

Quality Control

Our Barnidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.