Description

Barnidipine Hydrochloride is a high-purity active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is primarily valued for its potent and selective antihypertensive activity, offering a critical raw material for cardiovascular drug development and manufacturing. This compound is essential for pharmaceutical companies and research institutions focused on developing and producing advanced treatments for hypertension and related cardiovascular disorders.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antihypertensive medications.
• Cardiovascular Research: A key reference standard and investigational compound in preclinical and clinical studies for hypertension.
• Drug Development: Serves as a critical intermediate in the synthesis and process development of new calcium channel blocker drugs.
• Generic Drug Manufacturing: Used by generic pharmaceutical manufacturers to produce bioequivalent versions of branded antihypertensive drugs containing Barnidipine.
• Analytical Standard: Employed as a high-purity standard in quality control (QC) and analytical method development (e.g., HPLC, LC-MS) for drug testing.
• Academic & Clinical Studies: Utilized in university and hospital research settings to study vascular physiology and calcium channel mechanisms.

Basic Information

Product Name	Barnidipine Hydrochloride
CAS No.	104757-53-1
Molecular Formula	C27H29N3O6 • HCl
Molecular Weight	528.00 g/mol
Synonyms	Barnidipine HCl; Mepirodipine Hydrochloride; YM-09730-5; (±)-Barnidipine Hydrochloride; 3-[(1-Benzyl-3-piperidinyl)methyl] 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate Hydrochloride; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-(1-Benzyl-3-piperidinyl) Methyl Ester 5-Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Barnidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.