Description

3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl 1-(Phenylmethyl)-3-Pyrrolidinyl Ester, [R-(R*,R*)]- is a high-purity, stereochemically defined pharmaceutical intermediate with a complex molecular architecture. This compound is of significant value for its role in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in process development and the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly calcium channel blockers.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target APIs.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Product Name	3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, Methyl 1-(Phenylmethyl)-3-Pyrrolidinyl Ester, [R-(R*,R*)]-
CAS No.	104713-78-2
Molecular Formula	C27H28N2O6
Molecular Weight	476.53 g/mol
Synonyms	(R,R)-Nifedipine Impurity; (R,R)-Nifedipine Related Compound; Methyl 1-Benzyl-3-pyrrolidinyl (R,R)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (R,R)-BAY a 1040 Impurity; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenylmethyl)-3-pyrrolidinyl ester [R-(R*,R*)]-; (R,R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-benzyl-3-pyrrolidinyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Production follows GMP-compliant guidelines where applicable, and identity, purity, and chiral integrity are verified using advanced analytical techniques. Certificates of Analysis (COA) detailing specific lot results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.