Description

2-[4-(2,3-Dihydroxypropoxy)Phenyl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitro Phenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the 1,4-dihydropyridine class of compounds. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. Pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) need this precise intermediate to ensure the efficacy and purity of their final drug products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel 1,4-dihydropyridine-based calcium channel blockers and other therapeutic agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex molecules with specific stereochemistry and functional groups.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP-scale production of APIs.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and chemical methodology development.

Basic Information

Product Name	2-[4-(2,3-Dihydroxypropoxy)Phenyl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitro Phenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
CAS No.	104060-12-0
Molecular Formula	C29H34N2O9
Molecular Weight	554.59 g/mol
Synonyms	4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(2,3-dihydroxypropoxy)phenyl]ethyl] ester 5-methyl ester; 1,4-DHP derivative with 3-nitrophenyl and glyceryl ether substituents; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-(4-(2,3-dihydroxypropoxy)phenyl)ethyl) ester 5-methyl ester; Nitrendipine analog intermediate; Dihydropyridine calcium channel blocker intermediate; CAS 104060-12-0
EINECS	Contact for details

Quality Control

Our 2-[4-(2,3-Dihydroxypropoxy)Phenyl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitro Phenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.