Description

Cis Lacidipine CAS NO 103890-79-5 is a high-purity, stereochemically defined active pharmaceutical ingredient (API) belonging to the dihydropyridine class of calcium channel blockers. It is a critical intermediate and reference standard in the research and development of cardiovascular therapeutics, particularly for hypertension. This compound is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on innovating and producing next-generation antihypertensive medications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of advanced antihypertensive drugs.
• Reference Standard: Used in analytical method development, validation, and quality control (QC) testing for drug substances and finished products.
• Research & Development: Serves as a crucial compound in preclinical and clinical studies investigating calcium channel modulation.
• Process Chemistry: Employed in the optimization and scale-up of synthetic routes for dihydropyridine-based APIs.
• Impurity Profiling: Utilized to identify, characterize, and quantify stereoisomeric impurities in related pharmaceutical compounds.

Basic Information

Product Name	Cis Lacidipine
CAS No.	103890-79-5
Molecular Formula	C26H33NO6
Molecular Weight	455.55 g/mol
Synonyms	(±)-cis-Lacidipine; cis-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester; Lacidipine cis-isomer; Lacidipine Impurity C; (E)-4-[2-[3-(tert-Butoxy)-3-oxoprop-1-en-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
EINECS	Contact for details

Quality Control

Our Cis Lacidipine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (cis-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.