Description

Lacidipine is a potent, long-acting dihydropyridine calcium channel blocker used primarily in the treatment of hypertension. Its high selectivity for vascular smooth muscle makes it a critical active pharmaceutical ingredient (API) for formulating effective cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing antihypertensive drugs. The product is supplied as Lacidipine CAS NO 103890-78-4, meeting the stringent purity requirements for pharmaceutical synthesis and development.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive tablet formulations.
• Cardiovascular Drug Development: Key intermediate in research for new calcium channel blockers and combination therapies.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded lacidipine medications.
• Clinical Research: Used in preclinical and clinical studies to investigate dosage efficacy and new therapeutic applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories.
• Veterinary Medicine: Potential application in developing antihypertensive treatments for animals.

Basic Information

Product Name	Lacidipine
CAS No.	103890-78-4
Molecular Formula	C26H33NO6
Molecular Weight	455.55 g/mol
Synonyms	Lacidipinum; Lacidipino; GR-43659X; (±)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 2-[(2E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl] methyl ester; 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(tert-butoxycarbonyl)vinyl] 5-methyl ester; Lacipil (brand name); Motens (brand name)
EINECS	Contact for details

Quality Control

Our Lacidipine is manufactured under strict quality management systems. Each batch is tested to ensure compliance with pharmaceutical-grade specifications, typically referencing standards such as USP/EP monographs where applicable. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supported by validated analytical methods including HPLC, IR, and NMR. Our commitment ensures a reliable supply of high-purity API for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.