Description

(S)-Nisoldipine CAS NO 103573-38-2 is the single enantiomer of the dihydropyridine calcium channel blocker nisoldipine, representing a high-purity chiral intermediate of significant pharmaceutical importance. This optically pure compound is critical for research and development focused on stereoselective drug action and the synthesis of novel cardiovascular therapeutics. It is primarily required by pharmaceutical R&D laboratories, process chemistry teams, and manufacturers of active pharmaceutical ingredients (APIs) for investigating enantiomer-specific pharmacology and developing advanced formulations.

Application

• Key chiral intermediate in the research and synthesis of enantiomerically pure calcium channel blockers.
• Pharmacological reference standard for studying the stereoselective effects of nisoldipine in cardiovascular research.
• Starting material or building block for the development of novel dihydropyridine derivatives with improved therapeutic profiles.
• Critical component in analytical method development for the separation and quantification of nisoldipine enantiomers.
• Used in preclinical and clinical studies to understand the pharmacokinetics and metabolism of the (S)-enantiomer.
• Essential for process chemistry optimization in the scale-up of single-enantiomer API manufacturing.

Basic Information

Product Name	(S)-Nisoldipine
CAS No.	103573-38-2
Molecular Formula	C20H24N2O6
Molecular Weight	388.42 g/mol
Synonyms	(S)-Nisoldipine; (S)-Bay k 5552; (S)-1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl (3RS)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (S-enantiomer); (S)-3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-methylpropyl) ester, (S)-; S(-)-Nisoldipine
EINECS	Contact for details

Quality Control

Our (S)-Nisoldipine is manufactured under strict quality management systems to ensure high enantiomeric purity and chemical integrity, suitable for research and development applications. Each batch is characterized using advanced chiral analytical techniques, including HPLC and spectroscopic methods, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and related substance analysis is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and strictly light-sensitive; therefore, containers must be kept tightly sealed in a dark environment and opened only under controlled conditions to minimize exposure to moisture and light.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S)-enantiomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.