Description

Diltiazem Hydrochloride CAS NO 103532-27-0 is a high-purity pharmaceutical active ingredient belonging to the benzothiazepine class of calcium channel blockers. It is a critical intermediate and active pharmaceutical ingredient (API) used in the manufacture of cardiovascular medications. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for hypertension, angina, and certain cardiac arrhythmias. We supply this material with a focus on stringent quality control to meet the exacting standards of the global pharmaceutical industry.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of oral tablets, capsules, and extended-release formulations for cardiovascular therapy.
• Hypertension Treatment: Used in medications to manage high blood pressure by relaxing blood vessels.
• Angina Pectoris Management: Key component in drugs that prevent and treat chest pain caused by reduced blood flow to the heart.
• Cardiac Arrhythmia Control: Employed in specific antiarrhythmic therapies to control heart rate.
• Pharmaceutical Research & Development: Serves as a reference standard and starting material for new drug development and analytical method validation.
• Generic Drug Manufacturing: A vital raw material for producers of generic diltiazem hydrochloride medications.
• Veterinary Pharmaceuticals: Potential use in cardiovascular treatments for animals.

Basic Information

Product Name	Diltiazem Hydrochloride
CAS No.	103532-27-0
Molecular Formula	C22H26N2O4S • HCl
Molecular Weight	450.98 g/mol
Synonyms	(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride; Diltiazem HCl; Diltiazem Hydrochloride USP; (+)-cis-Diltiazem hydrochloride; CRD-401; Herbesser; Tildiem; Altiazem; Cardizem; Dilacor; Tiazac; Anginyl; Diltiazemum; Diltiazem (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Diltiazem Hydrochloride is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Quality is assured through a comprehensive battery of analytical tests including HPLC for assay and impurity profiling. We can supply material compliant with various pharmacopeial monographs, including USP. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from exposure to light to maintain stability and potency.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Optical Rotation	+115° to +120° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.